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Biological therapies for cardiac arrhythmias: can genes andcells replace drugs and devices? Circ Res. Given anappropriate question and a sufficient number of well-controlled studies, the statistical com-pilation of effects across studies in a meta-analysis can provide a highly credible evidence-based answer (Bartolucci, 2007; Glasziou, Vandenbroucke, & Chalmers, 2004; Nye,Vanryckeghem, Schwartz, Herder, Turner, & Howard, 2013). An additionalfactor in the approach to mechanical ventilationin the pediatric critical care setting is the tremen-dous variation in both patient age and size

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